Hypertrophic cardiomyopathy associated with left ventricular aneurysm and normal coronary arteries: Case study indicating genetic tendencies of cardiomyopathy

A 50-year-old man presented with hypertrophic obstructive cardiomyopathy (HOC) associated with a left ventricular aneurysm and normal coronary arteries. His history revealed no evidence of myocardial infarction or atypical angina. Physical examination disclosed HOC but did not suggest the presence of an aneurysm. Although the patient was treated medically, heart failure ensued, and he died suddenly while working his farm. Subsequent investigation of the patient's family revealed that three of his five children were also affected by cardiomyopathy, which was especially pronounced in the eldest, a 22-year-old man. The possible hemodynamic relationship between HOC and left ventricular aneurysm is discussed, along with probable indications. The role of left ventricular aneurysm is also presented in relation to the natural history of the disease.     

Particle selection in the nauplius of Calanus pacificus

Food selection by the nauplius of Calanus pacificus is definedas the ability to ingest certain kinds of particles in behavioralpreference to others that occur simultaneously in the same environment.Using mixtures of planktonic algae and plastic beads of differentor similar sizes, the nauplii strongly selected the algal cells,consuming them almost exclusively, and at similar rates to thecontrols with only algae. In some cases, however, ingestionrates on the algae were lower than the in the controls, mainlywhen the mixture was composed of algal cells and plastic beadsof smaller sizes able to be captured by the nauplii. Selectionof algal particles was also observed when pollen grains or detrituswere used instead of the plastic beads. Selection behavior alsooccurred when mixtures of two algae of different sizes wereoffered to the nauplii, and it was dependent on the proportionand concentration of both kinds of algae in the mixture. Thepossible effect of particle production on the observed selectivepatterns is discussed.     

A gel-forming (1→3)-β-D-glucan isolated from cyttaria harioti fischer

An alkali-soluble glucan, [α]_D + 11° (M potassium hydroxide) having a degree of polymerization of 220, has been isolated from the fruit bodies of the tree fungus Cyttaria harioti Fischer. Periodate oxidation and methylation analysis show that it consists of a highly branched β-D-(1→3)-linked backbone. Hydrolysis of the methylated polysaccharide yielded 2,3,4,6-tetra-O-methyl- (24.5 mol%), 2,4,6-tri-O-methyl-(39.4 mol%), 2,3,4-tri-O-methyl- (8.6 mol%), and 2,4-di-O-methyl-D-glucose (27.5 mol%). Periodate-oxidation results substantiate the methylation studies. The general structural features of the glucan are discussed.     

Genetic monitoring of inbred strains of mice using monoclonal antibodies to major histocompatibility haplotypes and lymphocyte alloantigens

An enzyme immunoassay procedure is described for the identification of major histocompatibility haplotypes and lymphocyte alloantigens in 19 inbred mouse strains. The assay was found to be useful for the genetic monitoring of such mice.